Dynamic gastrointestinal models as engineering tools to decipher food-microbiome-probiotic interactions
Véronique Delcenserie
Université de Liège, Liège, Belgique
Dynamic in vitro gastrointestinal models provide a mechanistic framework to study how dietary ingredients and microbiome-targeted interventions shape the human gut ecosystem. Using SHIME systems, we modeled interactions between human-derived microbial communities and selected food or probiotic formulations. Metataxonomic and functional analyses showed preserved overall diversity alongside selective modulation of beneficial microbial groups and metabolic outputs. Despite inter-individual variability, these results support the use of dynamic GI models as a flexible in vitro tool for microbiome engineering, while highlighting their current strenghts and limitations.